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Week 2 NFL Best Bets (2022)



After a crazy Week 1 where we got a feel for how teams are going to play this year, it’s time to continue into Week 2. There are a ton of good games this weekend, ranging from amazing divisional matchups like Saints-Buccaneers, to conference matchups like Bills-Titans. With all the great games this week, let’s take a look at some of my favorite bets, starting off with the Bills.

Buffalo Bills Prop Bets

*Player props weren’t available at the time of this article.

Buffalo Bills -10 (-110) 

The Buffalo Bills will host the Titans for the home opener this year and, after last week, they are going to be a tough team to beat. The offense looked amazing last week and that won’t change. The run defense last week looked a lot better than all of last year. Jordan Phillips coming back definitely helped that. This week, stopping the run is going to be the big task with Derrick Henry. Other than Henry, the Titans don’t pose too much of a threat. The Bills should cover easily.

Bills Point Range 28-35 (+145)

The Buffalo Bills offense is going to be able to move the ball very well this week and they proved last week that the red zone offense isn’t going to be a problem for them. (They converted both of their red zone attempts into touchdowns.) I expect the trend to continue this week and the Bills score around 35 points. This should be one of the safer bets this week.

First to call Timeout: Titans (-115)

I have a feeling that, no matter if the Titans start with the ball or on defense, they are going to have a problem and need to call a timeout early. On offense, I think they would need it for the crowd noise; it is going to be loud in that stadium and people are going to have a tough time hearing. If they start on defense, I think they will need a timeout just because the Bills are moving the ball so easily. 

Longest TD Over 42.5 (-115)

This is pretty much just a Bills bet here. The Titans can break off big plays but it is more likely that the Bills do this in the passing game. They have two very good vertical threats in Stefon Diggs and Gabe Davis. Either of these two can break off a big play or just beat their man one on one. I expect a long TD in this game.

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Around the NFL

Detroit Lions -1 (-115) 

This may seem like one of the more questionable bets, but hear me out. The Lions looked really good in a tough loss against the Eagles. I expect that production to continue against Washington this week. Dan Campbell might have turned this franchise around, at least in the locker room. I think that every single player there has bought into him and believes in him. They played a good Eagles team and went stride for stride with them. On offense, they put up 35 points and looked amazing running the ball. The Commanders run defense looked terrible last week, allowing James Robinson to find the end zone twice. The Lions keep the ball on the ground and will come out with a win on Sunday. 

New Orleans Saints +2.5 (-105)

After a shaky start to Week 1, the Saints seemed to figure it out in the second half. Jameis Winston looked great in the second half, throwing for over 200 yards and two touchdowns. The defense also improved, allowing only ten points in that timeframe. Since coming to Tampa Bay, Tom Brady has not beaten the Saints in the regular season. On top of that, Tampa has some injury issues after Week 1. WR Chris Godwin has a hamstring injury and hasn’t practiced all week and OT Donovan Smith is also on the injury report with an elbow. With this game being in New Orleans and the Buccaneers having some injury problems, I think that the Saints outright win this game… but take the points to be safe.

New York Giants -1 (-125)

The Carolina Panthers head to MetLife stadium for a meeting with the Giants. After a huge Week 1 win, the whole Giants team seems to have bought in to Brian Daboll. This looks like a recipe for another win this week. They ran the ball incredibly well, rushing for over 230 yards and Daniel Jones was efficient in the passing game, completing 81% of his passes (17/21). If they can continue to play that kind of football — running the ball and letting Jones make plays off the run game — they should continue to win.

Pittsburg Steelers +1 (+105)

The Steelers are at home and they aren’t being favored? This seems wrong. Their defense looked amazing last week, forcing five turnovers and sacking Joe Burrow seven times. T.J. Watt is hurt and that will have an impact on the pass rush but they should still be able to get to the QB. They are playing the New England Patriots, who looked really bad on offense last week. They only scored seven points and turned the ball over three times against Miami. I expect the Steelers defense to do the same thing this week.

*No bets are guaranteed to hit. Please gamble responsibly.

*Betting Odds via BetUS Sportsbook

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